Comparative efficacy (I)

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When comparing pradofloxacin with clindamycin, treatment with pradofloxacin resulted in a significant reduction of the total anaerobic count. A similar change could not be detected for clindamycin. The mean total anaerobic count was reduced by 80% in the pradofloxacin group compared to 8% in the clindamycin group. Hence, in contrast to clindamycin (bacteriostatic), pradofloxacin (bactericidal) was effective in reducing the total anaerobic count, an important finding as anaerobic bacteria play a major role in development and progression of periodontal disease.

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