Tablet (cats)

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In cats, treatment with Veraflox® tablets at the therapeutic dosage of 3 mg/kg resulted in rapid absorption, reaching peak concentrations of 1.2 mg/l within 0.5 hours.The bioavailability of pradofloxacin from the tablet formulation is at least 70%, with repeated daily dosing showing no impact on the pharmacokinetic profile (accumulation index = 1.0) 5,7.

When pradofloxacin is administered in tablets, the in vitro plasma protein binding is low (30%), and the high volume of distribution (Vd) >4 l/kg body weight indicates good tissue penetration. Pradofloxacin is eliminated from serum with a terminal half-life of 9 hours, and cleared from the body at 0.28 l/h/kg 17,19.

Serum pharmacokinetic profile of pradofloxacin tablets in cats

Cmax (mg/l)

Tmax (h)

t1/2 (h)

AUC0-24h (mg*h/l)

AUCinf (mg*h/l)

MRT (h)

Cl (l/h/kg)

V (l/kg)

F (%)

1.2

0.5

9.2

4.9

5.9

6.5

0.28

4.4

>70

Cmax: maximum concentration

Tmax: time of maximum concentration

t1/2: halflife

AUC0-24h: area under the concentration vs time curve (24h interval)

AUCinf: area under the concentration vs time curve (unlimited)

MRT: mean residence time

Cl: clearance

V: volume of distribution

F: bioavailability

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