In cats, treatment with Veraflox® tablets at the therapeutic dosage of 3 mg/kg resulted in rapid absorption, reaching peak concentrations of 1.2 mg/l within 0.5 hours.The bioavailability of pradofloxacin from the tablet formulation is at least 70%, with repeated daily dosing showing no impact on the pharmacokinetic profile (accumulation index = 1.0) 5,7.
When pradofloxacin is administered in tablets, the in vitro plasma protein binding is low (30%), and the high volume of distribution (Vd) >4 l/kg body weight indicates good tissue penetration. Pradofloxacin is eliminated from serum with a terminal half-life of 9 hours, and cleared from the body at 0.28 l/h/kg 17,19.
Serum pharmacokinetic profile of pradofloxacin tablets in cats
Cmax: maximum concentration
Tmax: time of maximum concentration
AUC0-24h: area under the concentration vs time curve (24h interval)
AUCinf: area under the concentration vs time curve (unlimited)
MRT: mean residence time
V: volume of distribution