Mutant Prevention Concentration (MPC) and Mutant Selection Window (MSW) of pradofloxacin in dogs and cats

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The risk of selection of resistant mutants in the bacterial population will decrease when drugs with lower MPC values are used. Consequently, it has been suggested to encourage use of the most potent drugs of a class only 34, 35, 36.
Due to the low MPC values for pradofloxacin against E. coli and S. intermedius, serum pradofloxacin concentration in dogs (given as tablet at 3 mg/kg) and in cats (given as oral suspension at 5 mg/kg) stays for a considerable period of time above these MPC values ensuring inhibition of both susceptible and first step mutants of these strains.

MPC, MIC, Mutant Selection Window and serum concentrations for pradofloxacin against S. intermedius and E. coli in dogs and cats.

Mutant Selection Window, MPC, MIC and serum concentration for pradofloxacin against E. coli (left) and S. intermedius (right) in dogs given as a tablet at 3 mg/kg

Mutant Selection Window, MPC, MIC and serum concentration for pradofloxacin against E. coli (left) and S. intermedius (right) in cats given as oral suspension at 5 mg/kg

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