Mutant prevention concentration profile

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Staphylococcus pseudointermedius

Bacterial resistance to antimicrobial agents is an undeniable fact and will continue to be a problem as long as these compounds are used. Since prior strategies have failed to slow the progression of bacterial resistance to antimicrobials, novel approaches for dealing with resistance are required.

The mutant prevention concentration (MPC) introduced by Dong and coworkers is a novel concept for the treatment of infectious diseases.16 Essentially, the MPC-concept favours a dose selection that not only ensures clinical cure but also minimises selection of bacterial resistance.

Bacterial populations naturally contain resistant variants (mutants). The minimum inhibitory concentration (MIC) of an antimicrobial defines the susceptibility of a bacterial isolate while the MPC determines the drug concentration needed to inhibit the least susceptible first step resistant mutant that can develop from this isolate.

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