MIC of pradofloxacin against anaerobic bacteria – periodontal infections

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MIC data is available for 630 strains of bacterial pathogens from dogs and cats, 310 Porphyromonas spp. and 320 Prevotella spp., provided by collaborating veterinarians across Europe who collected subgingival bacterial samples from dogs exhibiting clinical periodontal disease.


Pradofloxacin MIC data for the anaerobic pathogens from European studies 28, 29

 

Organism

Period

n

MIC Range

MIC50

MIC90

(µg/ml)

Porphyromonas spp.

2004-2006

310

≤ 0.016 - 0.5

0.062

0.125

Prevotella spp.

2004-2006

320

≤ 0.016 - 1

0.062

0.25

All anaerobes

2004-2006

630

≤ 0.016 - 1

0.062

0.25

 

 

Comparative susceptibility to pradofloxacin and metronidazole was determined using agar dilution CLSI methodology. Metronidazole was also highly active against these strains: 316 of 320 Prevotella strains (98.8%) and 309 of 310 Porphyromonas strains (99.7%) were susceptible (MIC ≤ 8 μg/ml). However, 3 Prevotella strains had intermediate metronidazole susceptibility (MIC = 16 μg/ml) while 1 Prevotella and 1 Porphyromonas strain were metronidazole resistant (MICs of 128 and 256 μg/ml, respectively).

 

Veraflox® demonstrated a high degree of activity against anaerobe pathogens isolated from clinical cases of periodontal disease and also showed activity against metronidazole resistant isolates29.

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