The MIC90 of pradofloxacin was compared to those of other antibiotics currently used in veterinary medicine, amoxicillin/clavulanic acid and other fluoroquinolones, e.g. difloxacin, enrofloxacin, marbofloxacin and orbifloxacin, in two large multi-centre studies between 1996 and 1999 in the U.S.10
Comparative in vitro activity against canine and feline bacterial pathogens
Number of strains
S. intermedius group
Pradofloxacin (PRA), enrofloxacin (ENR), marbofloxacin (MAR), difloxacin (DIF), orbifloxacin (ORB) and amoxicillin/clavulanic acid (A/C)
Pradofloxacin displayed excellent activity against each of the tested Gram-positive species. The activity of pradofloxacin clearly exceeded those of the comparator antibiotics. For Staphylococcus spp., Veraflox® is at least 2-4 times more active than other veterinary antibiotics tested. For the Gram-negative pathogens, the activity of pradofloxacin was similar or superior to that of the comparator antibiotics.
Veraflox® demonstrated superior in vitro activity to that of licensed antibiotics against mentioned Gram-positive veterinary pathogens, and superior or similar activity against mentioned Gram-negative veterinary pathogens10