Comparative MIC against aerobic bacteria

back

The MIC90 of pradofloxacin was compared to those of other antibiotics currently used in veterinary medicine, amoxicillin/clavulanic acid and other fluoroquinolones, e.g. difloxacin, enrofloxacin, marbofloxacin and orbifloxacin, in two large multi-centre studies between 1996 and 1999 in the U.S.10

Comparative in vitro activity against canine and feline bacterial pathogens

Pathogens

Number of strains

MIC90 (µg/ml)

PRA

ENR

MAR

DIF

ORB

A/C

S. intermedius group

200

0.06

0.12

0.25

0.25

0.5

≤0.25/0.12

E. coli

155

0.03

0.06

≤ 0.03

0.25

0.12

8/4

Staphylococcus spp.

129

0.12

0.25

0.5

0.5

1

0.5/0.25

Pasteurella spp.

32

≤0.015

≤0.03

≤0.03

≤0.06

≤0.06

≤0.25/0.12

 

Pradofloxacin (PRA), enrofloxacin (ENR), marbofloxacin (MAR), difloxacin (DIF), orbifloxacin (ORB) and amoxicillin/clavulanic acid (A/C)

 

Pradofloxacin displayed excellent activity against each of the tested Gram-positive species. The activity of pradofloxacin clearly exceeded those of the comparator antibiotics. For Staphylococcus spp., Veraflox® is at least 2-4 times more active than other veterinary antibiotics tested. For the Gram-negative pathogens, the activity of pradofloxacin was similar or superior to that of the comparator antibiotics.

 

Veraflox® demonstrated superior in vitro activity to that of licensed antibiotics against mentioned Gram-positive veterinary pathogens, and superior or similar activity against mentioned Gram-negative veterinary pathogens10

Rate this page

latest documents

3rd row with links